An Experimental Study on Airborne Landmine Detection Using a Circular Synthetic Aperture Radar

Many countries in the world are contaminated with landmines. Several thousand casualties occur every year. Although there are certain types of mines that can be detected from a safe stand-off position with tools, humanitarian demining is still mostly done by hand. As a new approach, an unmanned aerial system (UAS) equipped with a ground penetrating synthetic aperture radar (GPSAR) was developed, which is used to detect landmines, cluster munition, grenades, and improvised explosive devices (IEDs). The measurement system consists of a multicopter, a total station, an inertial measurement unit (IMU), and a frequency-modulated continuous-wave (FMCW) radar operating from 1 GHz to 4 GHz. The highly accurate localization of the measurement system and the full flexibility of the UAS are used to generate 3D-repeat-pass circular SAR images of buried antipersonnel landmines. In order to demonstrate the functionality of the system, 15 different dummy landmines were buried in a sandbox. The measurement results show the high potential of circular SAR for the detection of minimum metal mines. 11 out of 15 different test objects could be detected unambiguously with cm-level accuracy by examining depth profiles showing the amplitude of the targets response over the processing depth.Comment: 7 pages, 9 figure

On the Exploitation of CubeSats for Highly Accurate and Robust Single-Pass SAR Interferometry

Highly accurate digital elevation models (DEMs) from spaceborne synthetic aperture radar (SAR) interferometry are often affected by phase unwrapping errors. These errors can be resolved by the use of additional interferograms with different baselines, but this requires additional satellites in a single-pass configuration, resulting in higher cost and system complexity, or additional passes of the satellites, which affects mission planning and makes the system less suitable for monitoring fast-changing phenomena. This work proposes augmenting a bistatic SAR interferometer with one or more receive-only CubeSats, whose images are used to form an additional interferogram with a small baseline, making the system robust to unwrapping errors. In spite of the lower quality of the CubeSat images due to their small antenna aperture, this additional information can be used to detect and resolve phase unwrapping errors in the DEM without impacting its resolution or accuracy. A processing scheme for the phase unwrapping correction is presented along with a theoretical model for its performance. Finally, a design example is presented and discussed along with a simulation based on TanDEM-X data. It is also shown that CubeSat add-ons allow further increasing the baseline and thus improving the accuracy of DEMs. This concept represents a cost-effective solution for the generation of highly accurate, robust DEMs and paves the way to distributed SAR interferometric concepts based on CubeSats

Coherent measurements of a multistatic MIMO radar network with phase noise optimized non-coherent signal synthesis

For multistatic radar networks in the upper mm-wave range with a large spacing between its radar sensor nodes, a coherent signal distribution is very complex and thus very costly. Hence, it is desirable to generate the mm-wave signals individually for each radar sensor node, i.e., non-coherently. However, multistatic radar networks using a non-coherent signal distribution for its radar sensor nodes are affected by systematic errors and uncorrelated phase noise, which reduces the resolution and the detection performance of these systems. In this article, a novel non-coherent signal synthesis concept based on the direct digital synthesis (DDS) principle is presented for multistatic radar networks. Compared to a signal synthesis using a phase-locked loop (PLL), it is shown that the different phase noise behavior of the DDS is beneficial for bistatic signal paths between the radar sensor nodes. The presented hardware concept is considered and analyzed for three different types of coherency regarding the signal distribution: coherent, quasi-coherent, and incoherent. Measurements with a multiple-input multiple-output (MIMO) radar at 150GHz prove that despite 150 GHz prove that despite a non-coherent signal distribution, it is possible to achieve the same detection and imaging performance as with a fully coherent radar by using a DDS

Self-injury: Treatment, Assessment, Recovery (STAR): online intervention for adolescent non-suicidal self-injury - study protocol for a randomized controlled trial

Background: Non-suicidal self-injury (NSSI) is a clinically significant behavior affecting approximately 18% of adolescents and young adults worldwide. The importance of NSSI is supported by its association with a broad spectrum of mental disorders. Despite its high relevance, evidence-based, specific, time-, and cost-effective treatment approaches are scarce. Cognitive behavioral therapy (CBT) seems effective in reducing the frequency of NSSI in adolescents and young adults. However, young people are often reluctant to seek professional help and effective interventions adressing NSSI are not sufficiently available across all regions of Germany. Research indicates that the majority of youth with risk behavior (including NSSI) prefer technology-based interventions. To date, effective interventions for adolescents and young adults with NSSI that are deliverd online are not available. Methods: The present project aims to develop and evaluate an online intervention for adolescents and young adults with NSSI based on the content of a recently evaluated face-to-face short-term program that includes elements of CBT and dialectical behavior therapy (DBT): “The Cutting Down Programme” (CDP). The efficacy of the new online CDP intervention will be tested in a randomized controlled trial (RCT) in which n = 700 youths engaging in repetitive NSSI will participate in either an online psychoeducation (n = 350) or online CDP (n = 350). Within a postline assessment four months after baseline (end of treatment; T1), and follow-up evaluations 12 and 18 months after baseline (follow-ups; T2 and T3), NSSI and comorbid symptoms as well as quality of life will be assessed. It is hypothesized that participants receiving online CDP report a greater reduction in the frequency of NSSI within the last three months at T2 (primary endpoint) compared to those receiving online psychoeducation. Exploratory analyses will focus on predictors of treatment outcome. Discussion: We report on the development and evaluation of an online intervention for adolescents and young adults engaging in NSSI based on the CDP. If supported by empirical evidence, an online-based intervention for NSSI might help to overcome the limited availability of adequate interventions for youth. Trial registration: German Clinical Trials Register, DRKS00014623. Registered on 22 May 2018

Antibodies against CD20 or B-Cell Receptor Induce Similar Transcription Patterns in Human Lymphoma Cell Lines

BACKGROUND: CD20 is a cell surface protein exclusively expressed on B cells. It is a clinically validated target for Non-Hodgkin's lymphomas (NHL) and autoimmune diseases. The B cell receptor (BCR) plays an important role for development and proliferation of pre-B and B cells. Physical interaction of CD20 with BCR and components of the BCR signaling cascade has been reported but the consequences are not fully understood. METHODOLOGY: In this study we employed antibodies against CD20 and against the BCR to trigger the respective signaling. These antibodies induced very similar expression patterns of up- and down-regulated genes in NHL cell lines indicating that CD20 may play a role in BCR signaling and vice versa. Two of the genes that were rapidly and transiently induced by both stimuli are CCL3 and CCL4. 4 hours after stimulation the concentration of these chemokines in culture medium reaches a maximum. Spleen tyrosine kinase Syk is a cytoplasmic tyrosine kinase and a key component of BCR signaling. Both siRNA mediated silencing of Syk and inhibition by selective small molecule inhibitors impaired CCL3/CCL4 protein induction after treatment with either anti-CD20 or anti-BCR antibodies. CONCLUSION: Our results suggest that treatment with anti-CD20 antibodies triggers at least partially a BCR activation-like response in NHL cell lines

Cabozantinib in Advanced Hepatocellular Carcinoma: Efficacy and Safety Data from an International Multicenter Real-Life Cohort

Background and Aims: The multikinase inhibitor cabozantinib has been approved for hepatocellular carcinoma (HCC) previously treated with sorafenib. We report safety and efficacy data of an international, multicenter, real-life cohort of patients with advanced HCC treated with cabozantinib. Methods: Patients with HCC who were treated with cabozantinib were retrospectively identified across 11 centers in Austria, Switzerland, and Germany. Patients’ characteristics, adverse events, duration of treatment and overall survival (OS) data were analyzed until April 1, 2020. Results: Eighty-eight patients from 11 centers were included. The predominant underlying liver diseases were NAFLD/NASH in 26 (30%) and hepatitis C infection in 21 (24%) patients. Seventy-eight patients (89%) were classified as Barcelona clinic liver cancer (BCLC) stage C. Sixty patients (68%) were Child-Pugh A, whereas 22 (25%) were Child-Pugh B, respectively. Cabozantinib was used as systemic second- and third-line or later treatment in 41 (47%) and 46 (52%) patients, respectively. The following best responses under cabozantinib were documented: partial response in 6 (7%), stable disease in 28 (32%), and progressive disease in 28 (32%) patients, respectively. Fifty-two patients (59%) died during follow-up. The median OS from start of cabozantinib treatment was 7.0 months in the entire cohort and 9.7 months in Child-Pugh A patients, while Child-Pugh B patients had a median OS of 3.4 months, respectively. Thirty-seven (42%) patients fulfilled the CELESTIAL inclusion and exclusion criteria, showing a median OS of 11.1 months. Most common adverse events were fatigue (15.6%) and diarrhea (15.6%). Conclusion: Cabozantinib treatment was effective, safe, and feasible in patients with advanced HCC in patients with compensated cirrhosis. Patients in the real-life setting had more advanced liver disease – in which 25% of patients were Child-Pugh B. However, OS in patients with Child-Pugh A cirrhosis was similar to that reported in the phase 3 trial (CELESTIAL)

Physical Layer-Based Message Authentication inVANETs

Authenticating legitimate nodes is a major concern of the envisioned vehicular networks. To achieve this, standards and literature propose to use asymmetric cryptographic mechanisms which generate significant overheads in terms of time and power consumption. In this paper, we address this problem and we propose a novel idea of exploiting physical layer characteristics to rely on them for re-authenticating future beacons after verifying the first one cryptographically. Despite the challenges in such high mobility networks, possible concrete approaches to start the evaluation of our scheme are presented. Our approaches are inspired by the vehicular channel related work conclusions which give signs of future success to our scheme in this critical field